Inhibitionof N1-methylnicotinamide oxidase activity by a large amount of N1-methylnicotinamide injected into rats.
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چکیده
منابع مشابه
Preparation of 2- and 6-pyridones of N1-methylnicotinamide.
In the course of experiments designed to elucidate the structure of reduced diphosphopyridine nucleotide (DPNH) (12), it became necessary to prepare the 2and 6-pyridones of iV-methylnicotinamidel by oxidation of the latter. Huff (5) has described the preparation of N’-methyl-6-pyridone-3-carboxylic acid by alkaline ferricyanide oxidation of either trigonelline or N’-methylnicotinamide. The acid...
متن کاملConversion of monomethyl-l-tryptophan to niacin and N1-methylnicotinamide by the rat.
Gordon and Jackson (1) found that synthetic monomethyltryptophan was capable of stimulating growth in rats subsisting on a diet deficient in tryptophan. Chin (2) isolated kynurenine and kynurenic acid from the urine of rabbits after the parenteral administration of monomethylL-tryptophan (MMT). On the other hand, recent studies have shown that the albino rat, pig, horse, cotton-rat, and man can...
متن کاملNitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels.
N(1)-methylnicotinamide (MNA(+)) has until recently been thought to be a biologically inactive product of nicotinamide metabolism in the pyridine nucleotides pathway. However, the latest observations imply that MNA(+) may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium. We examined both in vivo and in vitro whether the compound might induce vasorelaxa...
متن کاملEstimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.
The in vivo conversion ratio of N1-methylnicotinamide (NMN) to N1-methyl-2-pyridone-5-carboxamide (2-PY) and N1-methyl-4-pyridone-3-carboxamide (4-PY) as a parameter for the estimation of aldehyde oxidase level in rats was examined. NMN and its pyridones (2-PY and 4-PY) are usually detected in the urine of rats. When we measured the ratio of the amount of pyridones to the total amount of NMN an...
متن کاملA fluorometric method for the determination of the 6-pyridone of N1-methylnicotinamide in urine.
Since Knox and Grossman demonstrated the excretion by man of the 6-pyridone of N’-methylnicotinamide (hereafter referred to as the pyridone) in appreciable amounts after the ingestion of nicotinamide (2), it became necessary to devise a method for its quantitative estimation in urine. Knox and Grossman isolated the compound from human urine and described its properties, including its ultraviole...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1989
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.53.2393